FMNL3 Antibody, FITC conjugated

Code CSB-PA815554LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FMNL3 Polyclonal antibody
Uniprot No.
Target Names
FMNL3
Alternative Names
FMNL3 antibody; FHOD3 antibody; FRL2 antibody; KIAA2014 antibody; WBP3 antibody; Formin-like protein 3 antibody; Formin homology 2 domain-containing protein 3 antibody; WW domain-binding protein 3 antibody; WBP-3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Formin-like protein 3 protein (2-212AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis. In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.
Gene References into Functions
  1. Study revealed an essential role for FMNL3 in regulating the RhoC/FAK pathway and actin assembly dynamics, and the subsequent promotion of colorectal carcinoma invasion. PMID: 30228782
  2. FMNL3, the target gene of miR-127, is upregulated and acting as an oncogene in ESCC PMID: 27645894
  3. FMNL3 functions in assembly of actin-based protrusions that are specialized for cell-cell adhesion. PMID: 25428984
  4. FMNL3 plays an important role in the progression and metastasis of colorectal carcinoma and may be a novel potential prognostic predictor in colorectal carcinoma. PMID: 25758200
  5. Formin-like 3 (FMNL3) is a crucial regulator of endothelial cell elongation during angiogenesis. PMID: 22275430
  6. Protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3. PMID: 22790947
  7. Data suggest that the FH2 domain of FRL2 possesses properties not shared by FRL1 that allow it to generate filopodia. PMID: 20862687

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Subcellular Location
Cytoplasm. Cell membrane; Lipid-anchor. Note=Enriched in lamellipodia.
Protein Families
Formin homology family
Tissue Specificity
Expressed in endothelial cells.
Database Links

HGNC: 23698

OMIM: 616288

KEGG: hsa:91010

STRING: 9606.ENSP00000335655

UniGene: Hs.179838

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